The Austrian Chemical Society (GÖCH)
Working Group of Organic Chemistry Presents The Adolf Lieben Lectureship 2020

Sponsored by TCI

Prof. Ilan Marek

14.12.2020, 1700 Hrs - 1830 Hrs

90 Minutes Event

Starts at 1700 Hrs and ends at 1830 Hrs

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Lecture will be held virtually on 14.12.2020

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Limited number of slots available for participants

ILAN MAREK

Ilan Marek is Professor at the Schulich Faculty of Chemistry at the Technion – Israel Institute of Technology. He holds the Sir Michael and Lady Sobell Academic Chair. He is a member of the French Academy of Sciences and a member of the Israel Academy of Sciences and Humanities.

Ilan Marek,
Technion – Israel Institute of Technology, Israel

Ilan Marek received his PhD in 1986 from the University Pierre et Marie Curie, Paris, France under the supervision of Prof. Jean Normant. Following post-doctoral studies at the University Catholique de Louvain-La-Neuve, Belgium with Prof. Leon Ghosez, backed to Paris he joined the CNRS in 1989. In 1997, he moved to the Technion – Israel Institute of Technology and currently holds the Sir Michael and Lady Sobell Academic Chair. Professor Marek’s honors include the RSC Organometallic Awards (2012), Israel Chemical Society Excellence Award (2012), Janssen Pharmaceutica Prize for Creativity in Organic Synthesis (2012), the Moore Distinguished Scholar Appointment from CalTech (2013), The Weizmann Prize for Exact Sciences (2015), The Yannai Award for Excellence in Teaching (2016), the Arthur C. Cope Scholar Award by the ACS  (2021). In 2017, he was elected Member of the French Academy of Sciences and in 2019, Member of the Israel Academy of Sciences and Humanities.

Ilan Marek is Professor at the Schulich Faculty of Chemistry at the Technion – Israel Institute of Technology.

https://ilanmarek.technion.ac.il/ilan-marek/

Remote Functionalization
(Merging metal-walk with C-C Bond Cleavage)

Ilan Marek
Schulich Faculty of Chemistry
Technion-Israel Institute of Technology
Haifa 3200009 Israel
E-mail: chilanm@technion.ac.il

Combining functionalization at a distant position from a reactive site with the creation of several consecutive stereogenic centers, including the formation of a quaternary carbon stereocenter, in acyclic system represents a pinnacle in organic synthesis. Here we report the regioselective Heck arylation of terminal olefins as a distant trigger for the ring-opening of cyclopropanes. This Pd-catalyzed unfolding of strained cycle, driving force of the chain-walking process, remarkably proved its efficiency and versatility, as the reaction proceeded regardless of the molecular distance between the initiation (double bond) and termination (alcohol) sites. Moreover, employing stereodefined polysubstituted cyclopropane vaults allowed to access sophisticated stereo-enriched acyclic scaffolds in good yields. Conceptually, we demonstrated that merging catalytically a chain walking process with a selective C–C bond cleavage represents a powerful approach to construct linear skeleton possessing several stereogenic centers.

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Prof. Nuno Maulide

Full Professor of Organic Synthesis, UniWien.  Adjunct PI at Research Center for Molecular Medicine, CeMM.

  • Währinger Straße 38, 1090 Wien
  • +43-1-4277-52156
  • patricia.emberger@univie.ac.at

Prof. Michael Schnürch

Associate Professor, Institute of Applied Synthetic Chemistry, TU Wien.

  • Getreidemarkt 9/163, 1060 Wien
  • +43 (1) 58801 - 163616
  • michael.schnuerch@tuwien.ac.at